OCT. 2024 COMPACT MILESTONE!

COMPACT-BASED IN VIVO DEEP-BRAIN CALCIUM RECORDING SPEEDS UP TO ~2,000 RPM ENABLING HIGH-THROUGHPUT MESOSCOPIC (3 MM X 5 MM FOV) DEEP-BRAIN IMAGING THROUGH A 0.5 MM IMAGING PROBE!

WE WILL WORK ON PUSHING FURTHER TO 6,000 RPM.

AUG. 2024 WE RECEIVED THE NEW NIH BRAIN R01 GRANT!

LIGHT PIPE MICROSCOPE FOR ULTRA-LARGE-SCALE CELLULAR-RESOLUTION WHOLE-NEOCORTEX TWO-PHOTON CALCIUM IMAGING OF MAMMALIAN BRAINS

The technology will enable whole-neocortex scale two-photon calcium imaging and allow mesoscopic calcium recording widely available at a very low cost.

JUN. 2024 OUR WHOLE MOUSE BRAIN SCALE TWO-PHOTON IMAGING RESULT WON THE 2024 BRAIN INITIATIVE PHOTO CONTEST! CONGRATS!

JUN. 2024 ZONGYUE PRESENTED THE DEEP BRAIN IMAGING TECHNOLOGY DURING THE SCHOLAR SPOTLIGHT LIGHTNING TALKS AT THE 10TH ANNUAL BRAIN INITIATIVE CONFERENCE.

MAY. 2024 MENG DELIVERED AN INVITED TALK AT ALLEN INSTITUTE ABOUT COMPACT!

FEB. 2024 OUR GTAO WORK IS PUBLISHED AT NATURE COMMUNICATIONS!

Using geometric transformation, the technology leverages aberration to dynamically correct spatially varying aberration for large-volume deep brain imaging.

"Geometric transformation adaptive optics (GTAO) for volumetric deep brain imaging through gradient-index lenses"

DEC. 2023 JIANIAN RECEIVED THE PRESTIGIOUS BILSLAND FELLOWSHIP. CONGRATULATIONS!

SEP. 2023 THE OPTICAL GEARBOX RECEIVED THE NIH SBIR GRANT TO ADVANCE HIGH-SPEED DEEP TISSUE IMAGING.

SEP. 2023 MENG DELIVERED AN INVITED LECTURE FOR THE VISION SCIENCE SEMINAR SERIES, "OXYOPIA," AT IU SCHOOL of OPTOMETRY.

AUG. 2023 WE HOSTED THE THIRD COMPACT TRAINING WORKSHOP AT PURDUE INTRODUCING THE NEW 0.5 MM COMPACT, DUAL-REGION COMPACT, AND SPINNING COMPACT.

APR. 2023 MENG RECEIVED THE HITACHI HIGH-TECH BEST PRESENTATION AWARD FROM SPIE PHOTONICS WEST 2023!

JAN. 2023 MENG DELIVERED INVITED TALK AT SPIE PHOTONICS WEST 2023!

NOV. 2022 MENG PRESENTED THE CLEARY OPTICALLY MATCHED PANORAMIC ACCESS CHANNEL TECHNIQUE (COMPACT) AT SFN 2022 IN SAN DIEGO!

NOV. 2022 MENG IS NOW AN ASSOCIATE EDITOR OF OPTICS EXPRESS!!

NOV. 2022 OUR WORK OPTICAL GEARBOX FOR SPEEDING UP BIOMEDICAL IMAGING IS PUBLISHED ON NATURE COMMUNICATION!

"Optical gearbox enabled versatile multiscale high-throughput multiphoton functional imaging"

OCT. 2022 IN COLLABORATION WITH UCSD STERNSON LAB, WE RECEIVED THE NIH U01 GRANT (1U01NS126054) TO ADVANCE DEEP BRAIN IMAGING TECHNOLOGIES!

AUG. 2022 MENG CONTRIBUTED TO A COLLABORATIVE REVIEW PAPER ON WAVEFRONT SHAPING AND DEEPING IMAGING IN RANDOM MEDIA!

"Roadmap on wavefront shaping and deep imaging in complex media"

JUN. 2022 MENG HOSTED THE COMPACT TRAINING WORKSHOP AT BINDLEY BIOSCIENCE CENTER!

JUN. 2022 OUR WORK ON ARBITRARY 3D PHASE PROFILE WRITING IN FUSED SILICA PUBLISHED ON OPTICS EXPRESS!

"Monolithic 3D phase profile formation in glass for spatial and temporal control of optical waves"

MAY. 2022 MENG DELIVERED AN INVITED TALK AT NATIONAL INSTITUTE ON DRUG ABUSE!

"Title: New generation of neurophotonics for multiscale access of mammalian brain"

APR. 2022 MENG RECEVIED PROMOTION TO ASSOCIATE PROFESSOR WITH TENURE! CONGRATULATIONS!

MAR. 2022 MENG SERVED AS LAFAYETTE REGIONAL SCIENCE AND ENGINEERING FAIR JUDGE!

MAR. 2022 MENG VISITED THE UNIV. OF MICHIGAN IN ANN ARBOR TO DELIVER THE BIOPHYSICS SEMINAR TALK!

DEC. 2021 ZONGYUE'S PAPER PUBLISHED ON BRAIN STIMULATION!

"High resolution ultrasonic neural modulation observed via in vivo two-photon calcium imaging"

DEC. 2021 ZONGYUE'S PAPER PUBLISHED ON OPTICA!

"Probing neuronal functions with precise and targeted laser ablation in the living cortex"

AUG. 2021 OUR COMPACT PAPER PUBLISHED ON NATURE METHODS!

"Clear optically matched panoramic access channel technique (COMPACT) for large-volume deep brain imaging"

This method enables two-three orders of magnitude increase in tissue access volume compared to the conventional miniature imaging probes. COMPACT leverages the ultrathin wall glass capillary and index matching to convert deep brain imaging into endoscopic imaging with the maximized access volume to device volume ratio. The next steps will be to adapt COMPACT for various applications with new engineering development such as further miniaturization, higher imaging speed, higher image resolution, probes for larger mammalian models, etc. The long-term goal is to transform the studies and understanding of deep mammalian brain functions through close collaboration with neuroscientists.

JUL. 2021 BOWEN PASSED THE THESIS DEFENSE FOR HIS PHD DEGREE! CONGRATULATIONS!

MAY. 2021 OUR INVENTION OF OPTICAL GEARBOX RECEIVED NIH GRANT R21EY032382!

The award will be for development of optical gearbox for high speed neural recording

OCT. 2020 HEHAI'S PAPER PUBLISHED ON OPTICS EXPRESS!

"Long-range remote focusing by image-plane aberration correction"

SEP. 2020 OUR COLLABORATION WITH UNIV. MICHIGAN RECEIVED THE NIH AWARD RF1MH124611

Development of a scalable strategy for reconstructing cell-type determined connectome of the mammalian brain

SEP. 2020 OUR COLLABORATION WITH UNIV. MINNESOTA RECEIVED THE NIH RO1 AWARD R01NS118330

Advancing simultaneous fmri-multiphoton imaging technique to study brain function and connectivity across different scales at ultrahigh field

SEP. 2020 COMPACT RECEIVED NIH AWARD U01NS118302

Optimization of clear optically matched panoramic access channel technique (compact) for large-scale deep-brain neurophotonic interface

AUG. 2020 CHENMAO'S PAPER PUBLISHED ON OPTICS EXPRESS!

"Line scanning mechanical streak camera for phosphorescence lifetime imaging"

AUG. 2020 JIANIAN'S PAPER PUBLISHED ON OPTICS EXPRESS!

"Jitter suppression for resonant galvo based high-throughput laser scanning systems"

AUG. 2020 ZONGYUE'S PAPER PUBLISHED ON OPTICS EXPRESS!

"Pupil plane actuated remote focusing for rapid focal depth control"

FEB. 2020 MENG AND TEAM MEMBERS DELIVERED FOUR RESEARCH TALKS AT SPIE PHOTONICS WEST 2020 IN SAN FRANCISCO!

• Large-scale femtosecond holography for near simultaneous optogenetic neural modulation

• Optical gearbox for kHz frame rate imaging

• High-precision in vivo ablation in mammalian brain with amplified femtosecond pulses

• Clear optically matched panoramic access channel technique (COMPACT) for large volume deep brain imaging

JAN. 2020 ZONGYUE'S PAPER PUBLISHED ON OPTICS EXPRESS!

"Contrast gain through simple illumination control for wide-field fluorescence imaging of scattering samples"

NOV. 2019 BOWEN PASSED HIS PRELIMINARY EXAM! CONGRATULATIONS!!

NOV. 2019 MENG RECEIVED THE PURDUE SEEDS FOR SUCCESS AWARD!

NOV. 2019 ZIJING'S PAPER PUBLISHED ON OPTICS EXPRESS!

"Off-axis spatiotemporally gated multimode detection toward deep fog imaging"

OCT. 2019 SHIYI'S PAPER PUBLISHED ON OPTICS EXPRESS!

"Large-scale femtosecond holography for near simultaneous optogenetic neural modulation"

OCT. 2019 MENG PRESENTED A POSTER AT SFN 2019

OCT. 2019 MENG DELIVERED AN INVITED TALK AT NORTHWEST UNIVERSITY

AUG. 2019 OUR COLLABORATION WITH UNIV. MICHIGAN RECEIVED THE NIH AWARD

This project is to develop high-throughput high-resolution hyperspectral imaging.

JUN. 2019 OUR NEW BOOK "WAVEFRONT SHAPING FOR BIOMEDICAL IMAGING" IS PUBLISHED

FEB. 2019 MENG DELIVERED AN INVITED TALK AT DUKE UNIVERSITY

JAN. 2019 MENG DELIVERED TWO INVITED TALKS IN TAIPEI AND HSINCHU, TAIWAN

SEP. 2018 OUR TEAM AWARDED THE NIH BRAIN INITIATIVE U01 AWARD

This project is to work on developing high-throughput deep-tissue imaging technologies.

APR. 2018 MENG DELIVERED AN INVITED TALK AT THE UNIVERSITY OF GEORGIA

FEB. 2018 MENG DELIVERED AN INVITED TALK AT THE UNIVERSITY OF NOTRE DAME

There was heavy fog during the driving to Notre Dame. Can we develop better imaging method to assist driving in heavy fog?

DEC. 2017 MENG DELIVERED AN INVITED TALK AT THE UNIVERSITY OF MICHIGAN IN ANN ARBOR

AUG. 2017 OUR WORK MPAO FEATURED AS THE COVER STORY OF LASER FOCUS WORLD

Meng holds the multifacet prism array, the key element of Multi-Pupil Adaptive Optics (MPAO)

JUN. 2017 OUR NEW PAPER PUBLISHED ON SCIENTIFIC REPORTS

"A proof-of-concept study for developing integrated two-photon microscopic and magnetic resonance imaging modality at ultrahigh field of 16.4 tesla"

To understand the signal origin of MRI BOLD signal, we developed a two-photon imaging system that can work simultaneously with high-field MRI without interference to each other.

Purdue News Room

MAY. 2017 OUR NEW PAPER PUBLISHED ON NATURE METHODS

Large-field-of-view imaging by multi-pupil adaptive optics

Purdue News Room

Brain-imaging Video Recorded By Multi-pupil Adaptive Optics

FEB. 2017 OUR NEW ARTICLE PUBLISHED ON NATURE LIGHT: SCIENCE & APPLICATION

"Random-access imaging of awake behaving animals"

JAN. 2017 LINGJIE KONG STARTED HIS NEW LAB AT TSINGHUA UNIV. IN CHINA

Dr. Lingjie Kong was recently awarded the 1000 young talent program selection. He will start his own research lab at Tsinghua University.

During his postdoc study, Lingjie did great work on pushing the envelop of high-throughput deep tissue imaging for neuroscience applications.

OCT. 2016 MENG RECEIVED THE PURDUE SEEDS FOR SUCCESS AWARD!

AUG. 2016 BOWEN WEI JOINED OUR LAB.

Bowen Wei received his BS degree in Physics from USTC, China in 2016. He will be pursuing his Ph.D. degree in ECE.

APR. 2016 OUR FORMER TEAM MEMBER RETO FIOLKA STARTED HIS RESEARCH TEAM AT UT SOUTHWESTERN IN THE DEPARTMENT OF CELL BIOLOGY

Reto is our former member from Jenelia Research Farm. He did great work on developing Adaptive Optics microscopy systems during his postdoc study in our lab.

FEB. 2016 JUNG-HOON PARK STARTED HIS NEW LAB AT UNIST IN KOREA

Dr. Jung-Hoon Park, postdoc of our team, started his new research team at the beautiful UNIST campus.

At our lab, Jung-Hoon did great work on conjugation Adaptive Optics.

OCT. 2015 OUR TEAM AWARDED THE NIH BRAIN INITIATIVE AWARD

The project is to develop and optimize a new form of deep tissue imaging method that can enable in vivo high resolution imaging of mammalian brains at tissue depths that are currently unavailable.