OCT. 2025
THE NEW OBJECTIVE LENS WORK THAT CORRECTS THE ABERRATION OF GRIN LENSES HAS BEEN PUBLISHED IN NATURE COMMUNICATIONS. CONGRATS TO THE DEEP-BRAIN OPTICAL IMAGING TEAM!
OCT. 2025
THE COLLABORATIVE WORK ON DEEP-BRAIN IMAGING WITH NTU AND NIH HAS BEEN PUBLISHED IN LASER & PHOTONICS REVIEWS!
OCT. 2025
THE LIGHT PIPE PROJECT RECEIVED THIS YEAR'S PURDUE SEED FOR SUCCESS AWARD. CONGRATS TO THE LIGHT PIPE TEAM!
AUG. 2025
MENG DELIVERED TWO INVITED TALKS AT SPIE OPTICS + PHOTONICS!
APR. 2025
MENG HAS BEEN SELECTED AS A PURDUE UNIVERSITY FACULTY SCHOLAR. CONGRATS!
OCT. 2024
COMPACT MILESTONE!
COMPACT-BASED IN VIVO DEEP-BRAIN CALCIUM RECORDING SPEEDS UP TO ~2,000 RPM ENABLING HIGH-THROUGHPUT MESOSCOPIC (3 MM X 5 MM FOV) DEEP-BRAIN IMAGING THROUGH A 0.5 MM IMAGING PROBE!
We will work on pushing further to 6,000 rpm.
AUG. 2024
WE RECEIVED THE NEW NIH BRAIN R01 GRANT!
LIGHT PIPE MICROSCOPE FOR ULTRA-LARGE-SCALE CELLULAR-RESOLUTION WHOLE-NEOCORTEX TWO-PHOTON CALCIUM IMAGING OF MAMMALIAN BRAINS
The technology will enable whole-neocortex scale two-photon calcium imaging and allow mesoscopic calcium recording widely available at a very low cost.
JUN. 2024
OUR WHOLE MOUSE BRAIN SCALE TWO-PHOTON IMAGING RESULT WON THE 2024 BRAIN INITIATIVE PHOTO CONTEST! CONGRATS!
JUN. 2024
ZONGYUE PRESENTED THE DEEP BRAIN IMAGING TECHNOLOGY DURING THE SCHOLAR SPOTLIGHT LIGHTNING TALKS AT THE 10TH ANNUAL BRAIN INITIATIVE CONFERENCE.
MAY. 2024
MENG DELIVERED AN INVITED TALK AT ALLEN INSTITUTE ABOUT COMPACT!
FEB. 2024
OUR GTAO WORK IS PUBLISHED AT NATURE COMMUNICATIONS!
Using geometric transformation, the technology leverages aberration to dynamically correct spatially varying aberration for large-volume deep brain imaging.
DEC. 2023
JIANIAN RECEIVED THE PRESTIGIOUS BILSLAND FELLOWSHIP. CONGRATULATIONS!
SEP. 2023
THE OPTICAL GEARBOX RECEIVED THE NIH SBIR GRANT TO ADVANCE HIGH-SPEED DEEP TISSUE IMAGING.
SEP. 2023
MENG DELIVERED AN INVITED LECTURE FOR THE VISION SCIENCE SEMINAR SERIES, "OXYOPIA," AT IU SCHOOL of OPTOMETRY.
AUG. 2023
WE HOSTED THE THIRD COMPACT TRAINING WORKSHOP AT PURDUE INTRODUCING THE NEW 0.5 MM COMPACT, DUAL-REGION COMPACT, AND SPINNING COMPACT.
APR. 2023
MENG RECEIVED THE HITACHI HIGH-TECH BEST PRESENTATION AWARD FROM SPIE PHOTONICS WEST 2023!
JAN. 2023
MENG DELIVERED INVITED TALK AT SPIE PHOTONICS WEST 2023!
NOV. 2022
MENG PRESENTED THE CLEARY OPTICALLY MATCHED PANORAMIC ACCESS CHANNEL TECHNIQUE (COMPACT) AT SFN 2022 IN SAN DIEGO!
NOV. 2022
MENG IS NOW AN ASSOCIATE EDITOR OF OPTICS EXPRESS!!
NOV. 2022
OUR WORK OPTICAL GEARBOX FOR SPEEDING UP BIOMEDICAL IMAGING IS PUBLISHED ON NATURE COMMUNICATION!
OCT. 2022
IN COLLABORATION WITH UCSD STERNSON LAB, WE RECEIVED THE NIH U01 GRANT (1U01NS126054) TO ADVANCE DEEP BRAIN IMAGING TECHNOLOGIES!
AUG. 2022
MENG CONTRIBUTED TO A COLLABORATIVE REVIEW PAPER ON WAVEFRONT SHAPING AND DEEPING IMAGING IN RANDOM MEDIA!
JUN. 2022
MENG HOSTED THE COMPACT TRAINING WORKSHOP AT BINDLEY BIOSCIENCE CENTER!
JUN. 2022
OUR WORK ON ARBITRARY 3D PHASE PROFILE WRITING IN FUSED SILICA PUBLISHED ON OPTICS EXPRESS!
MAY. 2022
MENG DELIVERED AN INVITED TALK AT NATIONAL INSTITUTE ON DRUG ABUSE!
"Title: New generation of neurophotonics for multiscale access of mammalian brain"
APR. 2022
MENG RECEVIED PROMOTION TO ASSOCIATE PROFESSOR WITH TENURE! CONGRATULATIONS!
MAR. 2022
MENG SERVED AS LAFAYETTE REGIONAL SCIENCE AND ENGINEERING FAIR JUDGE!
MAR. 2022
MENG VISITED THE UNIV. OF MICHIGAN IN ANN ARBOR TO DELIVER THE BIOPHYSICS SEMINAR TALK!
DEC. 2021
ZONGYUE'S PAPER PUBLISHED ON BRAIN STIMULATION!
DEC. 2021
ZONGYUE'S PAPER PUBLISHED ON OPTICA!
AUG. 2021
OUR COMPACT PAPER PUBLISHED ON NATURE METHODS!
This method enables two-three orders of magnitude increase in tissue access volume compared to the conventional miniature imaging probes. COMPACT leverages the ultrathin wall glass capillary and index matching to convert deep brain imaging into endoscopic imaging with the maximized access volume to device volume ratio. The next steps will be to adapt COMPACT for various applications with new engineering development such as further miniaturization, higher imaging speed, higher image resolution, probes for larger mammalian models, etc. The long-term goal is to transform the studies and understanding of deep mammalian brain functions through close collaboration with neuroscientists.
JUL. 2021
BOWEN PASSED THE THESIS DEFENSE FOR HIS PHD DEGREE! CONGRATULATIONS!
MAY. 2021
OUR INVENTION OF OPTICAL GEARBOX RECEIVED NIH GRANT R21EY032382!
The award will be for development of optical gearbox for high speed neural recording
OCT. 2020
HEHAI'S PAPER PUBLISHED ON OPTICS EXPRESS!
SEP. 2020
OUR COLLABORATION WITH UNIV. MICHIGAN RECEIVED THE NIH AWARD RF1MH124611
Development of a scalable strategy for reconstructing cell-type determined connectome of the mammalian brain
SEP. 2020
OUR COLLABORATION WITH UNIV. MINNESOTA RECEIVED THE NIH RO1 AWARD R01NS118330
Advancing simultaneous fmri-multiphoton imaging technique to study brain function and connectivity across different scales at ultrahigh field
SEP. 2020
COMPACT RECEIVED NIH AWARD U01NS118302
Optimization of clear optically matched panoramic access channel technique (compact) for large-scale deep-brain neurophotonic interface
AUG. 2020
CHENMAO'S PAPER PUBLISHED ON OPTICS EXPRESS!
AUG. 2020
JIANIAN'S PAPER PUBLISHED ON OPTICS EXPRESS!
AUG. 2020
ZONGYUE'S PAPER PUBLISHED ON OPTICS EXPRESS!
FEB. 2020
MENG AND TEAM MEMBERS DELIVERED FOUR RESEARCH TALKS AT SPIE PHOTONICS WEST 2020 IN SAN FRANCISCO!
Large-scale femtosecond holography for near simultaneous optogenetic neural modulation
Optical gearbox for kHz frame rate imaging
High-precision in vivo ablation in mammalian brain with amplified femtosecond pulses
Clear optically matched panoramic access channel technique (COMPACT) for large volume deep brain imaging
JAN. 2020
ZONGYUE'S PAPER PUBLISHED ON OPTICS EXPRESS!
